SpineDAO

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Spine Health

Revolutionizing spine care for millions worldwide. By leveraging blockchain, AI, and collaborative decentralized science, SpineDAO creates an open platform for optimizing surgical decisions, improving patient outcomes, and democratizing access to spine knowledge.

$SPINE

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Market Details

SOL

500M+ people suffer from spine-related conditions, making them one of the leading causes of disability and lost productivity across the globe.

$14 Billion

Estimated spine care market by 2031

500 Million+

People worldwide suffering from spine-related conditions

<$90 Million

NIH Budget for degenerative spine disease research between 2011 and 2021

Project

Additional Documentation

Litepaper

Pitch Deck

Spine care remains one of the most challenging and resource-intensive fields in modern healthcare. Spinal disorders, including degenerative diseases, deformities, trauma, and chronic back pain, represent a significant burden on healthcare systems worldwide. According to global health reports, over 540 million people suffer from spine-related conditions. The prevalence of conditions like osteoporosis, arthritis, herniated discs, and scoliosis is increasing due to aging populations, sedentary lifestyles and rising obesity rates.

Despite advancements in medical technologies and surgical techniques, spine care faces systemic inefficiencies that hinder optimal outcomes. These challenges include poor patient triage, inconsistent surgical strategies, fragmented post-operative follow-ups, and limited access to shared scientific knowledge. Furthermore, the siloed nature of healthcare data limits the potential of AI and machine learning algorithms to deliver impactful insights. This fragmented approach not only delays treatment but also results in significant financial and emotional costs for patients.

SpineDAO emerges as a decentralized science (DeSci) initiative designed to address the critical pain points in spine care. By leveraging decentralized technologies, AI, and a collaborative ecosystem of surgeons, researchers and patients, SpineDAO aims to create scalable, transparent, and efficient spinal solutions. Through its decentralized model, SpineDAO empowers stakeholders across the healthcare value chain to contribute, share, and benefit from data-driven innovations.

Additional Documentation

Litepaper

Pitch Deck

Dr. Vincent Challier

NYU Spine Research Institute research fellow , CHU Bordeaux Assistant Spécialist, Private Practice Spine Surgery Périgueux France

Dr. Virginie Lafage

Specialist in sagittal spinopelvic alignment, adult and cervical spinal deformities, and soft tissue analysis. With over 650 publications and leadership roles at NYU, HSS, and Lenox Hill Hospital, she co-founded Surgimap and mentors global spine researchers.

Dr. Joseph Cristini

Joseph Cristini is a French surgeon with a specialization in orthopedic surgery. He currently practices at the Hôpital privé Clairval Marseille, where he focuses on advanced surgical techniques for joint replacements and sports-related injuries.

Dr. Bassel Diebo

Dr. Bassel Diebo, fellowship-trained spine surgeon and Director of Spine Research at Brown University, specializes in complex spinal reconstruction, scoliosis, and posture alignment. With 250+ publications and global recognition, he’s a leading authority in spinal surgery innovation.

Dr. Guillaume Lonjon

Experienced Surgeon with a demonstrated history of working in the hospital & health care industry. Skilled in Clinical Research, Medical Education, Medicine, Research, and Hospitals. Strong healthcare services professional graduated from Université Paris Descartes.

Q2 2026

VECTOR SFCR 2026 — 2nd Prize Best Scientific Communication COMPLETED

Prospective multicenter validation of VECTOR AI triage algorithm presented at SFCR national congress (Marseille, June 11–13). Awarded 2nd prize best scientific communication. Multicenter study ongoing (500 patients, IRB-SOFCOT 21-2025)

Lamina Clinical AI Companion — VivaTech 2026 Demo COMPLETED

Lamina reached MVP production-hardening milestone. Presented at VivaTech 2026 (AI Factory France, June 19) alongside Virginie Lafage, pleias team. Four validated clinical modules: Triage & Referral, Follow-up Companion, Agentic Chat, Living Profile.

Q3 2026

TLIF-BAYES — Bayesian Multicenter Enrollment

Bayesian hierarchical multicenter retrospective trial comparing Open TLIF vs MIS-TLIF vs Endoscopic TLIF. 766 patients enrolled to date. Target: 600 (primary), 1,000 (pseudarthrosis sub-study). PI Dr. Anton Denisov; 13 SRC contributors.

VECTOR Commercialisation Launch

SaaS go-to-market for AI triage in spine clinics. Post-SFCR award validation; waitlist + demo pipeline active.

Lamina Clinic Deployment Pipeline

Production-hardened MVP ready for first clinical deployments. Partnership with pleias.

RADICULAR Track 2 — Molecule.xyz IP Asset

On-chain IP provenance for radicular peptide program. PeptAI partnership active.

Q4 2026

Track 2 Radicular — PeptAI Analog Engineering Pipeline

Non-sedating peptide analgesic program for lumbosacral radiculopathy. Engineered analogs of α2δ-1 decoy peptide (Chen et al. 2018). Computational candidate library → in vitro target engagement → in vivo efficacy vs gabapentinoid. PeptAI collaboration confirmed.

The global burden of low back pain: estimates from the Global Burden of Disease Study 2017

https://sciencedirect.com/science/article/abs/pii/S0140673619311250

Sagittal imbalance and spinal deformity: pathophysiology and radiographic classification

https://pubmed.ncbi.nlm.nih.gov/28234773

Risk Factors for Poor Outcomes in Spinal Deformity Surgery

https://sciencedirect.com/science/article/pii/S2666548424002555

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