Tackling the global crisis of chronic kidney disease through decentralized science and community-powered innovation. KidneyDAO funds early diagnostics, novel therapies, and collaborative data systems to reduce dialysis dependence and improve kidney health outcomes worldwide.
~34 Million
Adults in the U.S. are affected by Chronic Kidney Disease (CKD).
10–15 Years
Reduction in life expectancy due to Chronic Kidney Disease (CKD).
$130 Billion
In annual U.S. Medicare spending on kidney care.
Chronic Kidney Disease (CKD) affects over 10% of adults worldwide, shortens lives, and drives major healthcare costs—yet remains critically underfunded and under-researched.
Kidney disease is a silent epidemic affecting over 34 million adults in the U.S. alone. It can go undetected for years, leading to irreversible damage, reduced quality of life, and dramatically shortened life expectancy....
KLF15 Agonist Phase 1
Albuminuria/Proteinuria is a key factor in CKD, occurring when kidney filtration is damaged, allowing proteins like albumin to leak into urine. KLF15 is a promising therapeutic target for proteinuric kidney diseases, effectively suppressing pro-inflammatory and pro-fibrotic pathways, including TGF-β, a major contributor to kidney damage. Additionally, it modulates glucose and lipid metabolism in kidney cells, protecting against metabolic stress-induced injury. Thus, agents that enhance KLF15 expression or mimic its function could be potential therapies for proteinuria.
Early Detection and Diagnostics
Current Remote Patient Monitoring (RPM) devices are extremely expensive, and it is necessary to integrate this technology within smartphone applications for wider adoption. Contactless Facial RPM AI is an essential step toward progressive adoption of inexpensive RPM technologies, especially for CKD patients. KidneyDAO has signed an MOU to co-develop an RPM solution tailored for kidney health management. An additional component involves deeper penetration into rural healthcare via TeleHealth AI.
Smart Kidney Medication Patch
Not following medication routines or dosages is a major cause of disease progression, especially among elderly patients. For those needing high-quality care, real-time feedback is essential to automate delivery of necessary compounds in appropriate amounts. The Smart Kidney Medication Patch is being designed to enable automatic deployment of medication payloads via pain-free microneedles at preset intervals as well as in response to real-time physiological changes.
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Discord community
Telegram community
KidneyDAO captures value by co-developing intellectual property, forming translational research partnerships, and deploying token-based funding mechanisms for high-impact innovations in kidney health. Over the long term, the DAO may benefit from roya...
Medical Journal of Australia
Kidney disease: Improving global outcomes
Diabetes & Metabolic Syndrome: Clinical Research & Reviews
Chronic kidney disease and diabetes mellitus: A growing global health burden
Biosensors (MDPI)
